There were 3 very key points in the article:
1. Follow people. A lot of people.
Whether you're the last in your social group to sign up or the first, it helps to follow a whole lot of people. Don't just add the dozen or so of your friends who are tweeting; look up and add some of your favorite authors, newscasters, and others you trust to deliver information that has meaning for you. Don't be shy, and don't worry about offending them if you later decide to stop following them because they turn out to be too noisy, boring, or self-promotional for your tastes. Following or unfollowing someone is a one-click affair. But if you don't follow enough people to keep your stream filled with fresh tweets each day, you'll never get a real feel for how the conversation works.
2. Don't self-promote. (Or, at least, don't overdo it.)
The recent surge in Twitter's popularity has everyone thinking that joining Twitter is a smart way to boost their business, raise their public profile, or otherwise improve their social and monetary standing. In most cases, that's bull. If all you tweet about is your latest blog post, book, or other commercial venture, you'll quickly turn off most of the people who follow you. So even if you did sign up just for the hope of pecuniary gains, make a point of at least occasionally tweeting about something that real people might care about. If your followers are intrigued by the latest news story you've linked to, they might think twice about dumping you over all those get-rich-quick posts you've been spamming them with.
3. Use a Client App
Twitter's Web site is terrible. Even if it weren't constantly over capacity, its interface is static and unhelpful. But a decent client app will put all of Twitter's coolest features at your fingertips, as well as helpful third-party features like URL-shortening and photo support. I've tried most of the leading clients for Windows, Mac, and Linux, and my personal favorite across all three platforms is TweetDeck.
FYI...I use Tweetie on my iPhone and TweetDeck on my computers for Twitter, and I highly recommend both.
Read the whole article.